laugh, and the world laughs with you;
weep, and you weep alone.
for the sad old earth must borrow it's mirth,
but has trouble enough of its own.
sing, and the hills will answer;
sigh, it is lost on the air.
the echoes bound to a joyful sound,
but shrink from voicing care.
rejoice, and men will seek you;
grieve, and they turn and go.
they want full measure of all your pleasure,
but they do not need your woe.
be glad, and your friends are many;
be sad, and you lose them all.
there are none to decline your nectared wine,
but alone you must drink life's gall.
feast, and your halls are crowded;
fast, and the world goes by.
succeed and give, and it helps you live,
but no man can help you die.
there is room in the halls of pleasure
for a long and lordly train,
but one by one we must all file on
through the narrow aisles of pain.
the reason loneliness could be bad for your health
science has many uses, but it doesn't often produce handy pick-up lines. recent work on thegenetics of disease, however, suggest a way of opening a conversation with that solitaryattractive stranger in a bar: loneliness can make you ill.
lonely people, it seems, are at greater risk than the gregarious of developing illnessesassociated with chronic inflammation, such as heart disease and certain cancers. accordingto a paper published last year in the public library of science, medicine, the effect on mortalityof loneliness is comparable with that of smoking and drinking. it examined, and combined theresults of, 148 previous studies that followed some 300,000 individuals for an average periodof 7.5 years each, and controlled for factors such as age and pre-existing illness. it concludedthat, over such a period, a gregarious person has a 50% better chance of surviving than alonely one.
steven cole of the university of california, los angeles, thinks he may know why this is so. hetold the aaas meeting in washington, dc, about his work studying the expression of genes inlonely people. dr cole harvested samples of white blood cells from both lonely and gregariouspeople. he then analysed the activity of their genes, as measured by the production of asubstance called messenger rna. this molecule carries instructions from the genes telling acell which proteins to make. the level of messenger rna from most genes was the same inboth types of people. there were several dozen genes, however, that were less active in thelonely, and several dozen others that were more active. moreover, both the less active and themore active gene types came from a small number of functional groups.
broadly speaking, the genes less active in the lonely were those involved in staving off viralinfections. those that were more active were involved in protecting against bacteria. dr colesuspects this could help explain not only why the lonely are iller, but how, in evolutionaryterms, this odd state of affairs has come about. for inflammation is an antibacterial response.
the crucial bit of the puzzle is that viruses have to be caught from another infected individualand they are usually species-specific. bacteria, in contrast, often just lurk in theenvironment (like tetanus), and may thrive on many hosts (as does bubonic plague, forexample). the gregarious are therefore at greater risk than the lonely of catching viruses, anddr cole thus suggests that past evolution has created a mechanism (the details of whichremain unclear) which causes white cells to respond appropriately. conversely, the lonely arebetter off ramping up their protection against bacterial infection, which is a bigger relative riskto them.
what dr cole seems to have revealed, then, is a mechanism by which the environment (inthis case the social environment) reaches inside a person's body and tweaks its genome sothat it responds appropriately. it is not that the lonely and the gregarious are geneticallydifferent from each other. rather, their genes are regulated differently, according to howsociable an individual is. dr cole thinks this regulation is part of a wider mechanism that tunesindividuals to the circumstances they find themselves in. where it goes wrong is when lonelinessbecomes chronic, and the inflammatory response becomes chronic at the same time.
before civilisation intervened, such chronic loneliness would have been so rare (becauseisolated individuals are so vulnerable to predation) that evolution would have ignored it.now, paradoxically, the large population that civilisation makes possible means loneliness iscommonplace—and with it consequences that natural selection, which is blind to the future,has not yet had time to deal with.
did you try his friends? he doesn't really have any.
he's kind of a loner.
every kid has friends. did you check his computer?
if he's close to someone,he'd be e-mailing them.
and you know this how?
finding people is what i do. here's an idea.
how about you guys let me out,and i'll help you find him?
你们放我出去 我帮你们找 如何?
smart kid. he cleared his in-box.
i'm smart,too.a little hard disk recovery utility i like to use.
i'm a bit more old-fashioned in my techniques
pounding the pavement,knocking on doors,that sort of thing.
you're on salary.i get paid for delivery.
pounding the pavement is not a luxury that i get.
there's a receipt for a web site whosyourmomma.org.
it's expensive. he has a credit card?
well,he used one.
let's pull up a transaction record.
"mary margaret blanchard."
"mary margaret blanchard"
who's mary margaret blanchard?
谁是mary margaret blanchard?
as we build our birdhouses,remember,
what you're making is a home,not a cage.
the bird is free and will do what it will.
this is for them,not us.
they're loyal creatures.
if you love them and they love you,they will always find you.
we'll pick this up after recess. no running.
ms. mills,what are you doing here? mills
where's my son?
henry? i assumed he was home sick with you.
you think i'd be here if he was?
did you give him your credit card so he can find her?
i'm sorry. who are you?
i'm his... i'm his...
the woman who gave him up for adoption.
you don't know anything about this,do you?
不 真不巧 不知道
i should never have given him that book.
what in the hell is this book i keep hearing about?
just some old stories i gave him.
as you well know,henry is a special boy
so smart,so creative,and as you might be aware...
很聪明 很有创造力 或许你也意识到了...
he needed it. what he needs is a dose of reality.